A recent article published in Nature Reviews Immunology linked alterations of the microbes along mucosal tissues in the lungs, gut, and oral tissues, and pre-RA.
Microbiome
Major milestones in microbiome research that shaped understanding of autoimmune disease mechanisms.
How Diet Impacts Gut Immunity and Autoimmune Disease Risk
On August 21–22, 2024, the NIH Workshop on the Impact of Diet on Mucosal Immunity and Immune-Mediated Digestive Diseases brought together scientists, clinicians, and patient advocates to examine how nutrition influences immune health and disease risk. Hosted by the NIH Office of Nutrition Research and the National Institute of Allergy and Infectious Diseases, the event emphasized the […]
Do Gut Microbes Predict Multiple Sclerosis Severity?
In a study titled Gut microbial factors predict disease severity in a mouse model of multiple sclerosis, researchers use a preclinical mouse model of multiple sclerosis to pinpoint microbial factors in the pre-disease gut microbiome that could be linked to disease outcome. Finding microbial predictors of this disease is difficult in human cohort studies, as […]
Revolutionary Antibiotic Lolamicin Spares Gut Microbiome
Lolamicin, a Gram-negative antibiotic that targets harmful bacteria while preserving the gut microbiome is a novel treatment that may reduce the risk of autoimmune disease development and combat multidrug-resistant infections, offering a promising solution for safer antibiotic therapy.
Gut Dysbiosis Associated with Lupus Flares
A five-year study tracked microbes from fecal samples from systemic lupus erythematosus (SLE) patients to find out how gut microbes affect lupus flares. Their publication, Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares, documents their findings. The researchers found that the bacteria Ruminococcus gnavus increased during lupus flares. While they […]
Microbiome Composition Predicts Onset of Crohn’s Disease
All individuals harbor a diverse array of microbes within their gastrointestinal (GI) system, collectively known as the gut microbiome. Each person possesses a unique combination of microbes shaping this microbiome. For quite some time, researchers have hypothesized that the composition of the gut microbiome may play a crucial role in the development and/or progression of […]
Infant Gut Microbiome Holds Clues on Juvenile Idiopathic Arthritis
The NIH has compiled fact sheets outlining the current state of science on specific health topics. In the section titled “Autoimmune Diseases and Women’s Health,” the focus is specifically on autoimmune disease, highlighting several important points.
Addressing the Rapid Rise in Autoimmunity
A new review article titled The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention describes the increase in autoimmunity in recent years and how changes in our environmental exposures contribute to the increased prevalence of autoimmunity. Recent investigations have found that autoantibody frequencies are […]
Yale’s Groundbreaking Research on Gut-Brain Interactions to Combat Parkinson’s
An interdisciplinary team of doctors and scientists at Yale School of Medicine received a grant from the Aligning Sciences Across Parkinson’s (ASAP) initiative to study the link between the gut and the brain (also known as the gut-brain axis). This research can help scientists understand how the gut-brain axis influences the development of neurodegenerative diseases like Parkinson’s disease.
Study Finds Cesarean Section Linked to Crohn’s Disease Later in Life
A study titled Delivery mode and risk of gastrointestinal disease in the offspring that followed over a million full-term babies found a possible connection between Cesarean section (also known as C-section) delivery mode and the development of Crohn’s disease later in life.