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Autoimmune Disease List

There are over 90 known autoimmune diseases and counting, affecting at least 14.7 to 23.5 million Americans* – though research indicates that numbers have been growing steadily for years.

Many more conditions are autoimmune-related, or include suspected autoimmune components. With regard to some conditions, there can be differing opinions and conflicting research on various aspects and their relationships with autoimmunity. For more information and support, find your specific condition on our Autoimmune Organizations page.

This is an evolving list since many autoimmune diseases overlap, or exhibit comorbidities, and coexisting symptoms; some of the diseases listed here are variants or subtypes of other diseases. Also noted are rare autoimmune conditions – in the U.S., this means any disease affecting fewer than 200,000 people. In many cases, there exists such little information that the true prevalence is unknown. Our understanding of these conditions is constantly shifting as more information comes to light. 

The collection below is meant to serve as a helpful guide, and a starting point for your own research as a person with diagnosed or undiagnosed conditions – whether you’re unsure if you have an autoimmune disease or you think you may have more than one (having three or more is known as Multiple Autoimmune Syndrome or MAS).

*NOTE: GAI finds this number to be the most reputable estimation of autoimmune disease (AD) prevalence in the U.S. Nevertheless, we acknowledge that determining prevalence is a challenging task, and there are currently no up-to-date statistics. Taking into account undiagnosed and misdiagnosed individuals, as well as the rise in AD over the past few years, the number of cases in the U.S. is likely much higher.

*autoimmune-related or suspected autoimmune condition
rare disorder +


Acquired aplastic anemia +

Acquired hemophilia +

Acute disseminated encephalomyelitis (ADEM) +

Acute hemorrhagic leukoencephalitis (AHLE) / Hurst’s disease +

Agammaglobulinemia, primary +

Alopecia areata +

Ankylosing spondylitis (AS)

Anti-NMDA receptor encephalitis +

Antiphospholipid syndrome (APS) +


*Autism spectrum disorders (ASD)

Autoimmune Addison’s disease (AAD) +

Autoimmune dysautonomia / Autoimmune autonomic ganglionopathy (AAG)

Autoimmune encephalitis + 

Autoimmune gastritis

Autoimmune hemolytic anemia (AIHA) +

Autoimmune hepatitis (AIH) +

Autoimmune hyperlipidemia

Autoimmune hypophysitis / lymphocytic hypophysitis +

Autoimmune inner ear disease (AIED) +

Autoimmune lymphoproliferative syndrome (ALPS) +

*Autoimmune myelofibrosis +

Autoimmune myocarditis

Autoimmune oophoritis +

Autoimmune orchitis +

Autoimmune pancreatitis (AIP) / Immunoglobulin G4-Related Disease (IgG4-RD) +

Autoimmune polyglandular syndromes, types I, II, & III (APS type 1, APS type 2, APS type 3, APECED) +

Autoimmune progesterone dermatitis +

*Autoimmune sudden sensorineural hearing loss (SNHL)


Balo disease +

Behçet’s disease +

*Birdshot chorioretinopathy / birdshot uveitis

Bullous pemphigoid +


*Castleman disease +

Celiac disease

*Chagas disease

*Chronic fatigue syndrome (CFS) / myalgic encephalomyelitis (ME)

Chronic inflammatory demyelinating polyneuropathy (CIDP) +

*Chronic Lyme disease / post-treatment Lyme disease syndrome (PTLDS)

*Chronic urticaria (CU)

Churg-Strauss syndrome / eosinophilic granulomatosis with polyangiitis (EGPA) +

Cicatricial pemphigoid +

Cogan’s syndrome +

Cold agglutinin disease +

CREST syndrome / limited cutaneous systemic sclerosis +

Crohn’s disease (CD)

*Cronkhite-Canada syndrome (CSS) +

*Cryptogenic organizing pneumonia (COP)


Dermatitis herpetiformis +

Dermatomyositis +

Diabetes, type 1

Discoid lupus

*Dressler’s syndrome / postmyocardial infarction / postpericardiotomy syndrome




Eosinophilic fasciitis +

*Erythema nodosum

*Essential mixed cryoglobulinemia +

Evans syndrome +


*Fibrosing alveolitis


*Giant cell arteritis / temporal arteritis / Horton’s disease +


Goodpasture’s syndrome / anti-GBM/anti-TBM disease +

Granulomatosis with polyangiitis (GPA) / Wegener’s granulomatosis +

Grave’s disease +

Guillain-Barré syndrome (GBS) +


Hashimoto’s thyroiditis / chronic lymphocytic thyroiditis / autoimmune thyroiditis

Henoch-Schönlein purpura / IgA vasculitis +

Herpes gestationis / pemphigoid gestationis +

*Hidradenitis suppurativa



IgA nephropathy / Berger’s disease +

Immune thrombocytopenia (ITP) / autoimmune thrombocytopenic purpura +

*Interstitial cystitis


Juvenile idiopathic arthritis +


*Kawasaki disease +


Lambert-Eaton myasthenic syndrome (LEMS) +

*Leukocytoclastic vasculitis

Lichen planus +

*Lichen sclerosus +

*Ligneous conjunctivitis +

Linear IgA disease (LAD) / linear IgA bullous dermatosis (LABD) + 

Lupus nephritis


Ménière’s disease

Microscopic polyangiitis (MPA) +

Mixed connective tissue disease (MCTD) +

*Mooren’s ulcer

*Mucha-Habermann disease +

*Multifocal motor neuropathy +

Multiple sclerosis (MS)

Myasthenia gravis (MG) +


Neuromyelitis optica (NMO) / Devic’s disease +

*Narcolepsy +

Non-length-dependent small fiber sensory neuropathy (SFSN)


Ocular cicatricial pemphigoid +

*Opsoclonus-myoclonus syndrome (OMS) +


Palindromic rheumatism +

Palmoplantar pustulosis (type of psoriasis)  +

Paraneoplastic cerebellar degeneration +

Paraneoplastic pemphigus +

Paroxysmal nocturnal hemoglobinuria (PNH) +

*Peripheral uveitis / pars planitis +

Parsonage Turner syndrome +

Pemphigus foliaceus +

Pemphigus vulgaris +

*Pernicious anemia +

POEMS syndrome +

Polyarteritis nodosa +

Polymyalgia rheumatica +

Polymyositis +

*Postural Orthostatic Tachychardia Syndrome (POTS)

Primary biliary cholangitis (PBC) / primary biliary cirrhosis + 

*Primary sclerosing cholangitis (PSC)


Psoriatic arthritis +

*Pulmonary fibrosis, idiopathic (IPF) +

Pure red cell aplasia +

*Pyoderma gangrenosum +


*Raynaud’s phenomenon

Reactive arthritis / Reiter’s syndrome +

*Reflex sympathetic dystrophy syndrome

Relapsing polychondritis +

*Restless leg syndrome / Willis-Ekbom disease +

Rheumatic fever +

Rheumatoid arthritis



Schmidt syndrome +

Scleritis +

Scleroderma +

*Serpiginous choroidopathy +

Sjögren’s syndrome

*Stiff person syndrome (SPS) +

Systemic lupus erythematosus (SLE)

*Subacute bacterial endocarditis (SBE)

*Susac syndrome +

*Sydenham’s chorea

*Sympathetic ophthalmia


*Takayasu’s arteritis (vasculitis)

Testicular autoimmunity (vasculitis / orchitis)

*Tolosa-Hunt syndrome +

*Transverse myelitis (TM) +

*Tubulointerstitial nephritis uveitis syndrome (TINU)


Ulcerative colitis (UC) +

Undifferentiated connective tissue disease (UCTD)

*Uveitis, anterior

*Uveitis, intermediate

*Uveitis, posterior +




*Vogt-Koyanagi-Harada syndrome (VKH) +

Sources of information

With thanks to The Autoimmune Epidemic by Donna Jackson Nakazawa. Her well-researched book is rich with research and insights from various experts in the field of autoimmunity.

last updated January 2021

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