Anti-GBM disease (Goodpasture’s syndrome)

Anti-glomerular basement membrane (anti-GBM) disease, also known as Goodpasture’s syndrome, is a rare autoimmune disease in which the immune system produces antibodies that target the glomerular basement membrane in the kidneys and, in many cases, the lungs. This leads to inflammation and damage in these organs, often resulting in rapidly progressive glomerulonephritis and, when the lungs are involved, pulmonary hemorrhage.

Bleeding in the lungs, fatigue, nausea, breathing issues, vomiting, pale skin, burning sensations when urinating, blood in the urine, protein in the urine, coughing, foamy urine, swelling of the legs, and high blood pressure.

Hemoptysis, dyspnea, hypertension, arthritis, anemia, acute kidney failure, chronic kidney disease, heart disease, and respiratory failure.

Male sex, age between 20 and 30, or over 60, having certain genes, and environmental triggers such as exposure to chemicals or metallic dust, viral infections, smoking, hair dyes, hydrocarbon fumes, or certain medications.

• Autoimmunity in Anti-Glomerular Basement Membrane Disease: A Review of Mechanisms and Prospects for Immunotherapy (2023)
• Atypical Anti-Glomerular Basement Membrane Disease (2023)
• Subsequent COVID-19 Prophylaxis in COVID-19 Associated Glomerulopathies (2023)
• Relationship between anti-GBM antibodies and kidney outcomes in patients with anti-GBM disease (2023)