Pemphigus foliaceus

Characterized by the loss of intercellular adhesion of keratinocytes (keratin-producing skin cells) in the upper parts of the epidermis (surface layer of the skin), resulting in the keratinocytes separating from each other and being replaced by fluid (making blisters).

Blisters on the back, chest, and hands when the skin is rubbed, pruritus (itchiness), localized pain in affected areas.

Skin infections, sepsis, myasthenia gravis, and thymoma.

While the condition can affect people of any age, those most commonly affected are aged 50-60. There does seem to be a genetic component of the condition because the endemic form of the condition frequently occurs in family members who are genetically related. Can be induced by sun exposure, certain drugs/medications, or viruses from insect bites.

• The landscape of the immunologin repertoire in endemic pemphigus foliaceus (2023)
• From insect bites to a skin autoimmune disease: A conceivable pathway to endemic pemphigus foliaceus (2022)
• Network meta-analysis-based comparison of first-line steroid-sparing adjuvants in the treatment of pemphigus vulgaris and pemphigus foliaceus (2021)
• Beneficial effect of oclacitinib in a case of feline pemphigus foliaceus (2021)