Autoimmune Retinopathy (AIR)

Occurs when the immune system attacks the eye’s retina, causing inflammation.

Common symptoms are night blindness, visual field defects, episodic flashing lights (photopsia), changes in the pigment of the retina, and retinal tissue loss.

Symptoms may differ based on which retinal cells are affected, as CAR affects both cones and rods while MAR affects just rods.

Symptoms specific to cones: 

photopsia, photosensitivity, hemeralopia, loss of color vision, diminished visual acuity, and diminished central vision.

Symptoms specifically related to rods:

Photopsia, nyctalopia, prolonged dark adaptation, and peripheral visual field loss.

Non-paraneoplastic AIRs may coexist with Hashimoto’s thyroiditis, Grave’s disease, rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis, and bullous pemphigoid.

Risk factors differ based on the type of AIR present. MAR is more frequent in males, while females are more affected by CAR and non-paraneoplastic AIR. In addition, patients with non-paraneoplastic AIR are younger than those with the other forms. Individuals with a family history of autoimmune diseases may also be at greater risk for developing AIR.

• Serum antiretinal antibodies and cytokine profiling in autoimmune retinopathy and their association with clinical outcomes (2023)
• Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy (2023)
• Antireconverin antibodies in ocular chronic graft versus host disease: A new cause of nonparaneoplasic autoimmune retinopathy (2023)
• Plasma Antiretinal Autoantibody Profiling and Diagnostic Efficacy in Patients With Autoimmune Retinopathy (2023)