Autoimmune pancreatitis (AIP)

Also known as immunoglobulin G4-related disease, AIP is caused by an immune system attack on the pancreas which causes chronic inflammation, enlargement, or a mass in the pancreas. The subtypes of AIP are known as type 1 and type 2, and affect different parts of the body. Type 1 affects multiple organs; the pancreas, liver bile ducts, salivary glands, kidneys, and lymph nodes, while Type 2 only affects the pancreas.

Dark urine, pale and/or floating stool, nausea and vomiting, loss of appetite, unexplained weight loss, painless jaundice, upper abdomen and/ or middle back pain, weakness, and extreme fatigue.

Jaundice, ulcerative colitis, diabetes, pancreatic and bile duct stricture, pancreatic calcifications or stones, and pancreatic exocrine insufficiency.

AIP Type 1: 

Males aged 60 -70.

AIP Type 2:

Younger age; usually over 40, affecting males and females at equal rates. The frequency of both types varies according to geographical location.

• Autoimmune pancreatitis associated with inflammatory bowel diseases: A retrospectively bidirectional case-control study in China (2023)
• Autoimmune pancreatitis in patients with inflammatory bowel disease – a real-world multicentre collaborative ECCO CONFER study (2023)
• Autoimmune Pancreatitis: From Pathogenesis to Treatment (2022)
• Type 2 Autoimmune Pancreatitis: Consensus and Controversies (2022)
• Autoimmune pancreatitis and micronutrients (2023)