Polyarteritis nodosa (PAN)
Overview
A systemic blood vessel disease characterized by inflammation of small and medium-sized arteries which prevents their transport of oxygen and food to organs.
Common Symptoms
Fever, weight loss, loss of appetite, abdominal, joint, muscle, and/ or chest pain, shortness of breath, fatigue, and malaise. Ulcers and skin sores are also symptoms, along with polyneuropathy, palpable nodules along medium-sized arteries, high blood pressure, kidney function damage, and blood in stool.
Coexisting Diseases and Conditions
Microaneurysm formation, aneurysmal rupture with hemorrhage, thrombosis, organ ischemia, organ infarction, and polyneuropathy.
Risk Factors and Prevalence
Increased incidence of PAN has been observed following hepatitis B infection.
Recent Research
- Efficacy and safety of treatments in cutaneous polyarteritis nodosa: A French observational retrospective study (2022)
- Clinical approach to diagnosis and therapy of polyarteritis nodosa (2021)
- 2021 American College of Rheumatology/Vasculitits foundation guideline for the management of polyarteritis nodosa (2021)
- Sequence-based screening of patients with idiopathic polyarteritis nodosa, granulomatosis with polyangiitis, and microscopic polyangiitis for deleterious genetic variants in ADA2 (2020)
Sources
- Article Sources
Polyarteritis Nodosa. (n.d.). Johns Hopkins Vasculitis Center. Retrieved June 12, 2021, from https://www.hopkinsvasculitis.org/types-vasculitis/polyarteritis-nodosa/
Polyarteritis Nodosa: Background, Pathophysiology, Etiology. (2021). https://emedicine.medscape.com/article/330717-overview
Polyarteritis Nodosa (PAN): Symptoms, Treatment & Outcomes. (n.d.). Cleveland Clinic. Retrieved June 12, 2021, from https://my.clevelandclinic.org/health/diseases/13284-polyarteritis-nodosa