Postural orthostatic tachycardia syndrome (POTS)


Related to blood volume, the primary indicator of POTS is orthostatic intolerance, which is when too little blood returns to the heart when moving from a lying down to a standing up position.

There are multiple variations of POTS, which include:

Neuropathic POTS
Hyperadrenergic POTS
Low blood volume POTS
Secondary POTS

Common Symptoms

Dizziness/lightheadedness, fainting, high or low blood pressure, chest pain, abdominal pain, brain fog (trouble concentrating and cognitive dysfunction), headaches, insomnia, heart palpitations, fatigue, excessive sweating, and nausea.

Risk Factors and Prevalence

POTS is most common among females between the ages of 15 and 45 years old. Specific gene polymorphisms have also been reported to be associated with the syndrome. Viral illnesses, infections, pregnancy, and trauma are other risk factors.


  1. Article Sources
    1. Dysautonomia International: Postural Orthostatic Tachycardia Syndrome. (n.d.). Retrieved July 27, 2021, from

    2. Gunning, W. T., Kvale, H., Kramer, P. M., Karabin, B. L., & Grubb, B. P. (2019). Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated GProtein Coupled Receptor Autoantibodies. Journal of the American Heart Association, 8(18), e013602.

    3. Postural Orthostatic Tachycardia Syndrome (POTS). (n.d.). Retrieved July 27, 2021, from

    4. Postural Tachycardia Syndrome Information Page | National Institute of Neurological Disorders and Stroke. (n.d.). Retrieved July 27, 2021, from

    5. Postural tachycardia syndrome (PoTS). (2017, October 19). Nhs.Uk.

    6. POTS: Causes, Symptoms, Diagnosis & Treatment. (n.d.). Cleveland Clinic. Retrieved July 27, 2021, from