Pemphigus foliaceus



Characterized by the loss of intercellular adhesion of keratinocytes (keratin-producing skin cells) in the upper parts of the epidermis (surface layer of the skin), resulting in the keratinocytes separating from each other and being replaced by fluid (making blisters).

Common Symptoms

Blisters on the back, chest, and hands when the skin is rubbed, pruritus (itchiness), localized pain in affected areas.

Coexisting Diseases and Conditions

Skin infections, sepsis, myasthenia gravis, and thymoma.

Risk Factors and Prevalence

While the condition can affect people of any age, those most commonly affected are aged 50-60. There does seem to be a genetic component of the condition because the endemic form of the condition frequently occurs in family members who are genetically related. Can be induced by sun exposure, certain drugs/medications, or viruses from insect bites.


  1. Article Sources
    1. Lepe, K., Yarrarapu, S. N. S., & Zito, P. M. (2021). Pemphigus Foliaceus. In StatPearls. StatPearls Publishing.

    2. Pemphigus Foliaceus: Background, Pathophysiology, Etiology. (2021).

    3. Pemphigus foliaceus | DermNet NZ. (n.d.). Retrieved June 12, 2021, from

    4. Pemphigus—Symptoms and causes. (n.d.). Mayo Clinic. Retrieved June 12, 2021, from