Palmoplantar pustulosis (PPP)



A rare, recurrent inflammatory disease typically associated with psoriasis, characterized by painful or burning pustules (small bumps on the skin that contain fluid or pus) on the palms of the hands and soles of the feet.

Common Symptoms

Pustules on the palms and/or the feet, patches of thick, red, scaly skin, itching, pain, and feelings of burning in the hands and/or feet.

Coexisting Diseases and Conditions

Plaque psoriasis, psoriatic arthritis, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), celiac disease, thyroid disease, type 1 diabetes, and streptococcal tonsillitis.

Risk Factors and Prevalence

Females aged 40-58, cigarette smoking, bacterial infections such as acute or chronic tonsillitis, dental infection, or chronic sinusitis, contact allergies, certain medications, family history of PPP, or psoriasis.


  1. Article Sources
    1. American Osteopathic College of Dermatology. (n.d.). Palmoplantar Pustulosis .

    2. NORD (National Organization for Rare Disorders). (2020, April 15). Palmoplantar Pustulosis. NORD (National Organization for Rare Disorders).,and%20cause%20a%20burning%20feeling

    3. Oakley, A. (n.d.). Palmoplantar pustulosis. Palmoplantar pustulosis | DermNet NZ.