Immune thrombocytopenia (ITP)/Autoimmune thrombocytopenia purpura

Immune thrombocytopenia (ITP), also known as autoimmune thrombocytopenia purpura, involves low levels of cells that help with blood clotting, resulting in significant bruising or bleeding. This can be chronic in adults, but full recoveries can typically be expected for children.

Easy or excessive bruising, particularly from the gums or nose, superficial bleeding into the skin on the lower legs (appears as petechiae – pinpoint, round spots that appear on the skin), blood in urine, stools, or vomit, unusually heavy menstrual flow, purple bruises, and frequent nosebleeds.

Systemic lupus erythematosus, hepatitis C, type 1 diabetes, renal failure, lymphoma, and leukemia.

ITP is two to three times more common in females than in males, occurring more often in younger females. Sometimes the reason that ITP develops is unknown, but some of the conditions that may be triggers are infections (such as HIV, hepatitis, mumps, or flu), medications that cause an allergy that cross-reacts with platelets, pregnancy, autoimmune diseases (such as SLE or rheumatoid arthritis, or antiphospholipid syndrome), and low-grade lymphomas and leukemias.

• ITP-Immune throbocytopenic purpura (2023)
• Idiopathic thrombocytopenic purpura in pregnancy (2023)
• The approach to managing the patients with idiopathic thrombocytopenic purpura: A case-control study (2020)
• Complement activation in patients with immune throbocytopenic purpura according to phases of disease course (2020)