Goodpasture’s syndrome/Anti-GBM/anti-TBM disease
Overview
Autoantibodies attack the lungs and kidneys and if left untreated this can quickly escalate to glomerulonephritis, kidney failure, or even death.
Common Symptoms
Bleeding in the lungs, fatigue, nausea, breathing issues, vomiting, pale skin, burning sensations when urinating, blood in the urine, protein in the urine, coughing, foamy urine, swelling of the legs, and high blood pressure.
Coexisting Diseases and Conditions
Hemoptysis, dyspnea, hypertension, arthritis, anemia, acute kidney failure, chronic kidney disease, heart disease, and respiratory failure.
Risk Factors and Prevalence
Male sex, age between 20 and 30, or over 60, having certain genes, and environmental triggers such as exposure to chemicals or metallic dust, viral infections, smoking, hair dyes, hydrocarbon fumes, or certain medications.
Recent Research
- Autoimmunity in Anti-Glomerular Basement Membrane Disease: A Review of Mechanisms and Prospects for Immunotherapy (2023)
- Atypical Anti-Glomerular Basement Membrane Disease (2023)
- Subsequent COVID-19 Prophylaxis in COVID-19 Associated Glomerulopathies (2023)
- Relationship between anti-GBM antibodies and kidney outcomes in patients with anti-GBM disease (2023)
Sources
- Article Sources
Goodpasture Syndrome. (n.d.-a). NORD (National Organization for Rare Disorders). Retrieved June 12, 2021, from https://rarediseases.org/rare-diseases/goodpasture-syndrome/
Goodpasture Syndrome. (n.d.-b). Retrieved June 12, 2021, from https://www.hopkinsmedicine.org/health/conditions-and-diseases/goodpasture-syndrome
Goodpasture Syndrome (Anti-GBM Disease): What It is & Diagnosis. (n.d.). Cleveland Clinic. Retrieved July 12, 2021, from https://my.clevelandclinic.org/health/diseases/5927-goodpasture-syndrome