Discoid lupus erythematosus (DLE)
Overview
A type of lupus that is limited to the skin and presents as coin-shaped lesions on the skin form, either localized (on the face, ears, scalp) or disseminated (above and below the neck).
Common Symptoms
Red, inflamed patches with a scaling and crusty appearance, skin peeling, thickening of the scalp and patches of hair loss.
Coexisting Diseases and Conditions
Diabetes mellitus, scarring alopecia, and vasculitis. DLE has been identified to occur as a manifestation of systemic lupus erythematosus (SLE) in about 20% of patients.
Risk Factors and Prevalence
Females aged 40-60, African Americans, and environmental factors including exposure to UV rays and smoking.
Recent Research
- Pediatric discoid lupus erythematosus: Short report (2022)
- Discoid lupus erythematosus solely involving the eyelids: case report and literature review (2021)
- The role of interleukin-17 (IL-17) in the pathogenesis of discoid lupus erythematosus and lichen planopilaris: is immunohistochemistry for IL-17 a promising way to differentiate these entities? (2022)
- Risk factors of progression from discoid lupus to severe systemic lupus erythematosus: a registry-based cohort study of 164 patients (2023)
Sources
- Article Sources
Böckle, B. C., & Sepp, N. T. (2015). Smoking is highly associated with discoid lupus erythematosus and lupus erythematosus tumidus: Analysis of 405 patients. Lupus, 24(7), 669–674. https://doi.org/10.1177/0961203314559630
Kuechle, M. K., & Elkon, K. B. (2007). Shining light on lupus and UV. Arthritis Research & Therapy, 9(1), 101. https://doi.org/10.1186/ar2100
McDaniel, B., Sukumaran, S., & Tanner, L. S. (2021). Discoid Lupus Erythematosus. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK493145/
Santiago-Casas, Y., Vilá, L. M., McGwin, G., Cantor, R. S., Petri, M., Ramsey-Goldman, R., Reveille, J. D., Kimberly, R. P., Alarcón, G. S., & Brown, E. E. (2012). Association of Discoid Lupus with Clinical Manifestations and Damage Accrual in PROFILE: A Multiethnic Lupus Cohort. Arthritis Care & Research, 64(5), 704–712. https://doi.org/10.1002/acr.21581