Cryptogenic organizing pneumonia (COP)

A rare lung condition that affects the alveoli (air-exchange sacs), the walls of the small bronchi, and bronchioles (small airways). Symptoms appear when these tissues become inflamed and clogged with debris. COP is typically only diagnosed when all other possible explanations for illness have been eliminated. If the condition is left untreated, it can lead to severe lung damage.

Typically, flu-like symptoms are the first sign of COP. These may be accompanied by shortness of breath, dry cough, weight loss, chest pain, joint pain, night sweats, fever, chills, fatigue, and hemoptysis (coughing up blood).

Systemic lupus erythematosus, rheumatoid arthritis, scleroderma, primary biliary cirrhosis, ulcerative colitis, Crohn’s disease, Sweet syndrome, sarcoidosis, Behçhet disease, and primary pulmonary lymphoma.

COP typically affects people between the ages of 50 and 60. Autoimmune conditions or inflammatory diseases (such as rheumatoid arthritis or granulomatosis) may also increase the risk of developing COP.

• Update on cryptogenic organizing pneumonia (2023)
• Does cryptogenic organizing pneumonia change seasonal? (2023)
• Scoping review: The state of research on cryptogenic organizing pneumonia therapeutics (2022)
• Spontaneous resolution of cryptogenic organizing pneumonia: Observational study (2023)