Overview
CCS is a non-hereditary disease affecting the gastrointestinal tract, with a possible autoimmune etiology. It is primarily characterized by the formation of polyps, or abnormal tissue growths.
Cronkhite-Canada Syndrome (CCS)
Common Symptoms
Changes in taste and loss of smell, polyps in the stomach, small intestine, colon, and less frequently in the esophagus, chronic or recurring watery diarrhea, abdominal discomfort, feeling of general ill health (cachexia), malnutrition, nausea and vomiting, alopecia, loss of fingernails, and hyperpigmentation (darker spots on the skin).
Coexisting Diseases and Conditions
Risk Factors and Prevalence
CSS affects more men than women, with a 3:2 ratio reported in the literature. In addition, the condition’s age of onset occurs in the early 60’s.
Recent Research
- The genomic landscape of Cronkhite-Canada syndrome: Possible clues for pathogenesis (2022)
- Cronkhite-Canada syndrome: treatment responses and improved overall survival (2023)
- Endoscopic and Pathological Characteristics of Cronkhite- Canada Syndrome: A Retrospective Analysis of 76 Cases (2022)
- Cronkhite-Canada Syndrome Mimicking COVID-19-related Symptoms (2022)
Case Report
Sources
- Article Sources
Cronkhite-Canada Syndrome. (n.d.). NORD (National Organization for Rare Disorders). Retrieved June 15, 2021, from https://rarediseases.org/rare-diseases/cronkhite-canada-syndrome/
Taylor, S. A., Kelly, J., & Loomes, D. E. (2018). Cronkhite-Canada Syndrome: Sustained Clinical Response with Anti-TNF Therapy. Case Reports in Medicine, 2018, e9409732. https://doi.org/10.1155/2018/9409732
Ward, E. M., & Wolfsen, H. C. (2003). Pharmacological management of Cronkhite–Canada syndrome. Expert Opinion on Pharmacotherapy, 4(3), 385–389. https://doi.org/10.1517/14656566.4.3.385
Werness, Bruce. (February 18, 2020). A GI Odyssey: Cronkhite-Canada Syndrome Case Report.
Cronkhite-Canada Syndrome. Rare Disease Database, NORD.