Bullous pemphigoid

A skin disease characterized by large fluid-filled blisters on the areas that flex, such as the lower abdomen, upper thighs, or armpits, due to autoantibodies targeting the skin.

Itchy skin (pre-blister formation), large, tough blisters along creases/folds in the skin, reddish/darker skin around blisters, eczema, rashes, and small mouth sores.

Psoriasis, lichen planus, diabetes, rheumatoid arthritis, ulcerative colitis, and multiple sclerosis.

Risk increases with age as it typically only affects older individuals. Males tend to be more commonly affected than females. There are known genetic predispositions to the disease. Patients with neurological diseases, including strokes, dementia, Parkinson’s disease, and psoriasis are at increased risk. Certain medications, injuries, or skin infections can also be triggers.

• Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid (2023)
• Comorbidity in bullous pemphigoid: up-date and clinical implications (2023)
• Bullous Pemphigoid and Human Leukocyte Antigen (HLA)-DQA1: A Systematic Review (2023)
• Assessment of relationships between bullous pemphigoid and neurological diseases: A bidirectional two-sample Mendelian randomization study (2023)
• Bullous pemphigoid (BP) patients with selective IgG autoreactivity against BP230: Review of a rare but valuable cohort with impact on the comprehension of the pathogenesis of BP (2022)