Autoimmune progesterone dermatitis (APD)



A reaction to the progesterone hormone produced during the menstrual cycle, causing various eruptions to form on the skin.

Common Symptoms

Hives (urticaria), itchy inflammation from eczema, swelling under the skin from angioedema, and anaphylaxis (a life-threatening allergic reaction) may also occur.

Coexisting Diseases and Conditions

Atopic dermatitis (eczema) or erythema multiforme.

Risk Factors and Prevalence

APD most commonly occurs in females in their 30’s and risk increases with use of progesterone-only oral contraceptives.


  1. Article Sources
    1. Baptist, A. P., & Baldwin, J. L. (2004). Autoimmune progesterone dermatitis in a patient with endometriosis: Case report and review of the literature. Clinical and Molecular Allergy, 2(1), 10.

    2. Detrixhe, A., Nikkels, A. F., & Dezfoulian, B. (2017). Autoimmune progesterone dermatitis. Archives of Gynecology and Obstetrics, 296(5), 1013–1014.

    3. Macchi, G., Marchesi, G. F., & Quattrini, A. (1967). [New contributions to the study of efferent connections of the nuclei of the median intralaminar line of the thalamus. Bollettino della Societa italiana di biologia sperimentale, 43(21), 1414–1418.

    4. You, H. R., Yun, S. J., Kim, S. J., Lee, S.-C., Won, Y. H., & Lee, J.-B. (2017). Three Cases of Autoimmune Progesterone Dermatitis. Annals of Dermatology, 29(4), 479–482.