Autoimmune myocarditis
Overview
Myocarditis is inflammation of the heart muscle, which reduces your heart’s ability to pump and causes heart arrhythmias. The specific underlying cause is currently unknown, but infection with a virus or drug reaction has been known to cause the condition.
Common Symptoms
Chest pain, abnormal heartbeat, shortness of breath, fatigue, fever, headaches, sore throat, leg swelling, and diarrhea.
Coexisting Diseases and Conditions
Lupus, rheumatic fever, Kawasaki disease, and amyloidosis.
Risk Factors and Prevalence
Having 20-51 years of age, being male, having an autoimmune disease that affects the heart, viral and bacterial infections, taking certain cancer therapeutics, and having general inflammation are risk factors.
Recent Research
- Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis (2022)
- Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism (2023)
- Myocarditis and autoimmunity (2023)
- Aggravation of TGFβ1-Smad Pathway and Autoimmune Myocarditis by Fungicide (Tebuconazole) Exposure (2023)
- STING regulates the transformation of the proinflammatory macrophage phenotype by HIF1A into autoimmune myocarditis (2023)
Sources
- Article Sources
Autoimmune myocarditis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. (n.d.). Https://Rarediseases.Info.Nih.Gov/Diseases/9519/Autoimmune-Myocarditis. Retrieved July 12, 2021, from https://rarediseases.info.nih.gov/diseases/9519/autoimmune-myocarditis
Myocarditis. (n.d.). NORD (National Organization for Rare Disorders). Retrieved June 12, 2021, from https://rarediseases.org/rare-diseases/myocarditis/
Myocarditis—Symptoms and causes. (n.d.). Mayo Clinic. Retrieved June 12, 2021, from https://www.mayoclinic.org/diseases-conditions/myocarditis/symptoms-causes/syc-20352539