Infection-Associated Chronic Illness Provider Manual
First of Its Kind from Mount Sinai
Mount Sinai’s Cohen Center for Recovery from Complex Chronic Illness (CoRE) has released a first-of-its-kind Infection-Associated Chronic Illness (IACI) Provider Manual, a comprehensive, evidence-based guide for clinicians treating patients with conditions linked to infections. These include long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and chronic tick- and vector-borne illnesses such as post-treatment Lyme disease syndrome.
The manual, described as a living document that will be updated every 6 months, aims to fill a significant gap in medical education and clinical resources.
Although millions of people worldwide live with these often-debilitating conditions, most healthcare providers receive little to no formal training in their recognition and management.
Without clear, research-based guidance, patients can face years of delayed diagnoses, ineffective treatments, and unnecessary suffering.
Developed by a multidisciplinary team at the Icahn School of Medicine at Mount Sinai, the manual provides practical recommendations across the entire care spectrum—from initial assessment and diagnosis to long-term management strategies and referrals to appropriate specialists. It emphasizes a patient-centered approach, balancing evidence-based treatments with supportive care that addresses quality of life.
The resource is available free of charge to clinicians worldwide.
To access it, providers complete a brief form; responses help the CoRE team understand who is using the manual and guide future updates. Once submitted, the manual is available for immediate download, and users can also explore upcoming CME-accredited courses and other educational opportunities from Mount Sinai.