Overview
Essential mixed cryoglobulinemia is a rare immune-mediated/autoimmune condition that features cryoglobulins, which are abnormal proteins in the blood that clump together at temperatures below 98.6 degrees Fahrenheit. The clumping of these proteins can restrict blood flow to the body’s joints, muscles, and organs, which can cause vasculitis (inflammation of the blood vessels). The body’s smaller blood vessels are more typically affected, but larger blood vessels can also be involved.