Pemphigus vulgaris

 

 

Overview

The more common of the two forms of pemphigus, which is an autoimmune disease that causes blisters on your skin and mucous membranes to rupture, creating open sores that may become infected.  

Common Symptoms

Mouth blisters, skin or genital mucous membrane blisters, swollen or reddened skin around the nails, hoarse voice, nasal congestion, nutritional deficiencies, and nasal bleeding.

Coexisting Diseases and Conditions

If left untreated, pemphigus vulgaris can cause life-threatening erosions in the skin, mucosal membranes, and other tissues. It has also been linked to secondary bacterial infections, fungal infections such as candida, viral infections like herpes simplex, anxiety, and depression.

Risk Factors

Triggers for autoantibodies’ attacks on the skin and mucous membrane cells remains a mystery, but on rare occasions may follow using certain drugs such as angiotensin-converting enzyme inhibitors or penicillamine. The risk of incidence for pemphigus vulgaris is more significant beginning with middle-age and was found to be higher for those of Middle Eastern or Jewish ancestry.

Sources

  1. Article Sources and Footnotes
    1. Crown. (2018, October 2). Pemphigus vulgaris. NHS Choices. https://www.nhs.uk/conditions/pemphigus-vulgaris/

    2. Mayo Clinic Staff. (2020, October 24). Pemphigus. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/pemphigus/symptoms-causes/syc-20350404

    3. Ngan, V. (2019, January). Pemphigus vulgaris. Pemphigus vulgaris | DermNet NZ. https://dermnetnz.org/topics/pemphigus-vulgaris/

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