Autoimmune pancreatitis (AIP)

 

 

Overview

Also known as immunoglobulin G4-related disease, AIP is caused by an immune system attack on the pancreas which causes chronic inflammation, enlargement, or a mass in the pancreas. The subtypes of AIP are known as type 1 and type 2, and affect different parts of the body. Type 1 affects multiple organs; the pancreas, liver bile ducts, salivary glands, kidneys, and lymph nodes, while Type 2 only affects the pancreas.

Common Symptoms

Dark urine, pale and/or floating stool, nausea and vomiting, loss of appetite, unexplained weight loss, painless jaundice, upper abdomen and/ or middle back pain, weakness, and extreme fatigue.

Coexisting Diseases and Conditions

Jaundice, ulcerative colitis, diabetes, pancreatic and bile duct stricture, pancreatic calcifications or stones, and pancreatic exocrine insufficiency.

Risk Factors

AIP Type 1: 

Males aged 60 -70.

AIP Type 2:

Younger age; usually over 40, affecting males and females at equal rates. The frequency of both types varies according to geographical location.

Sources

  1. Article Sources and Footnotes
    1. Autoimmune Pancreatitis: Symptoms, Treatments & Tests. (n.d.). Cleveland Clinic. Retrieved July 12, 2021, from https://my.clevelandclinic.org/health/diseases/17936-autoimmune-pancreatitis

    2. Autoimmune pancreatitis—Symptoms and causes. (n.d.). Mayo Clinic. Retrieved July 12, 2021, from https://www.mayoclinic.org/diseases-conditions/autoimmune-pancreatitis/symptoms-causes/syc-20369800

    3. Fan, B.-G., & Andrén-Sandberg, Å. (2009). Autoimmune pancreatitis. North American Journal of Medical Sciences, 1(4), 148–151. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364658/

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