Cronkhite-Canada Syndrome (CSS) is a sporadic disorder characterized by polyposis of the digestive tract, and ectodermal abnormalities. CSS is a very rare, progressive disease. Its etiology may be related to immune dysregulation, particularly autoimmunity.
Treatment includes supportive measures such as correcting fluid, electrolyte, and protein loss and regulating stool frequency, immunosupressive therapy, and/or surgery for complications.
Other possible diagnoses for individuals with similar symptoms: