Vaccine Manufacturers

Pfizer COVID-19 Vaccine Immune Responses in Axial Spondyloarthritis Patients

A Comment piece was recently published in The Lancet regarding a small study evaluating the immunogenicity of the Pfizer COVID-19 vaccine in 17 axial spondyloarthritis patients on TNF or IL-17A inhibitors. “All patients were managed according to treatment guidelines; secukinumab (150 mg) was administered every four weeks, and adalimumab (40 mg) was administered either every 2 weeks or every three weeks.”

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Results of Com-Cov Mix-and-Match Vaccine Study

The Com-Cov2 study tested the efficacy and safety of mix-and-matching COVID-19 vaccines, including Pfizer, AstraZeneca, Moderna and Novavax. Moderna or Novavax vaccines were administered 8-12 weeks after a first dose of the Pfizer or AstraZeneca vaccine, measuring for IgG antibodies at 28 days after the second dose.

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Hybrid Immunity in Autoimmune Rheumatic Disease Patients

Researchers at the Center For Arthritis and Rheumatism Excellence in Kerala, India, tested immune responses in autoimmune rheumatic disease patients (AIRD) after one dose of a COVID-19 vaccine following a SARS-CoV-2 infection versus two doses of a COVID-19 vaccine without a previous infection. 

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Antibody Responses in Pfizer-Vaccinated Immunocompromised Patients

Researchers in Israel conducted a prospective cohort study analyzing antibody responses in immunocompromised patients after receiving the Pfizer COVID-19 vaccine. This cohort of patients was not included in original COVID-19 vaccine clinical trials, but they may benefit most from vaccination as they experience higher mortality rates from COVID-19 compared to immunocompetent persons.

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