Sjögren’s Syndrome

Sjögren's Syndrome occurs when the glands responsible for producing moisture in the eyes, mouth, and other parts of the body are destroyed by autoantibodies. Below are COVID news and research updates that specifically relate to Sjögren's.

COVID-19 Vaccine Tolerance in Patients with Rheumatoid Arthritis

Researchers created an online questionnaire for RA and AIRD patients to self-report short-term COVID-19 vaccine-related adverse events. Vaccines included in the study were Pfizer, Moderna, Johnson & Johnson, AstraZeneca, Covaxin, and Sinopharm. The most common coexisting autoimmune diseases were thyroid disorders, systemic lupus erythematosus (SLE) and Sjogren’s syndrome (10.0%, 2.6%, and 2.5%, respectively).

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Long COVID & Systemic Autoimmune Rheumatic Diseases

Those suffering from systemic autoimmune rheumatic diseases have an increased risk of severe outcomes from a COVID-19 infection. Due to factors such as altered immunity or the use of immunosuppressive medications, they may also be at risk of developing Long COVID.

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SLE Flares Post COVID-19 Vaccine

A study in Japan analyzed the association between mRNA Covid-19 vaccination and medium-term SLE flare-ups. At 30 days after completion of a primary series, the rate of mild or moderate SLE flares was 20.3% within the vaccinated group, versus 23.3% in the unvaccinated group. Flare rates at 60 and 90 days were similar between both groups. 

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Covid-19 Outcomes in Autoimmune Disease Patients

Autoimmune disease is currently considered a risk factor for severe COVID-19. A research article published in Rheumatology last Fall summarized 30-day outcomes of autoimmune disease (AD) patients following hospitalization with COVID-19. AD patients diagnosed and/or hospitalized between January and June 2020 with COVID-19 were included, and their 30 day outcomes were compared to patients with at least one AD hospitalized with influenza from September 2017 through April 2018.

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