Autoimmune Diseases

Weighing the Pros and Cons of Pausing Methotrexate for COVID shots

A recently published study in the Annals of the Rheumatic Diseases analyzed the pros and cons of pausing methotrexate usage. The group that continued their regular medication regimen demonstrated a 55% antibody response from the COVID vaccines whereas the group that paused methotrexate demonstrated an 80% antibody response.

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Assessing the Safety of mRNA COVID-19 Vaccination in the Immunocompromised

In a research article published yesterday in Frontiers in Oncology, COVID-19 vaccine (Pfizer and Moderna) safety was evaluated in a population of 566 immunocompromised patients including those with hematological malignancies (131), solid tumors (191), immune-rheumatological diseases (86), and neurological disease (158) including multiple sclerosis and generalized myasthenia.

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FDA Updates Recommendation Around AstraZeneca’s Evusheld

The FDA has revised its emergency use authorization for AstraZeneca’s Evusheld, a monoclonal antibody treatment for COVID-19. Due to emerging data, it has been observed that the original 150mg dose of each monoclonal antibody may be less likely to prevent infection than originally indicated. Thus, the FDA has authorized a double dose of each antibody for immunocompromised patients.

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