Autoimmune Diseases

Vaccine Efficacy in SLE Patients Across Multiple Variants

A new study investigated vaccine efficacy of a primary series and booster dose across multiple variants, including the BA.1 omicron variant, in SLE patients. This is one of the first studies on vaccine efficacy of a primary series and booster dose across multiple variants, including the BA.1 omicron variant, especially in an autoimmune disease patient cohort.

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Autoantibodies linked to ADs associated with COVID-19

Several studies have reported autoantibody production being induced by COVID-19 infection though we still do not understand their full spectrum. This work reinforces the idea that a COVID-19 infection may trigger serious autoimmune disease, “suggesting that this occurs against multiple molecules with key functions in immune and vascular homeostasis such as GPCRs and RAS-related molecules.”

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Molecular and Immunological Evidence for SARS-CoV-2 being the Autoimmune Virus

“This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases.”

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Treating COVID-19 with Immune Modulator Drugs

Topline results of a recent clinical trial showed that infliximab or abatacept “substantially improve[ed] clinical status and reduc[ed] deaths” in adult patients hospitalized with severe COVID-19. These drugs are often used to treat certain autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and ankylosing spondylitis.

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