Paraneoplastic pemphigus

 

Overview

The least common but most severe form of pemphigus disease resulting in painful blisters on the mouth, lips, skin, and esophagus. Typically associated with cancer.

Common Symptoms

Oral blisters, skin lesions, itchiness, as well as respiratory and/or gastrointestinal issues.

Coexisting Diseases and Conditions

B-cell lymphoma, chronic lymphocytic leukemia, Castleman’s disease, Waldenstrom’s macroglobulinemia, thymoma, and myasthenia gravis.

Risk Factors and Prevalence

Age between 45 and 70 years. Children with Castleman’s disease, a disease caused by enlarged lymph nodes, are commonly affected by this condition. At this time, there are no known correlations between the disease’s incidence and any sex, race, or place of origin.

Sources

  1. Article Sources and Footnotes

    1. Goldberg, L. J., MD. (2021, March 26). Paraneoplastic Pemphigus: Background, Pathophysiology, Etiology. 

    2. Paraneoplastic pemphigus: a short review. (2016). PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042195/#:%7E:text=Paraneoplastic%20pemphigus%20(PNP)%20is%20a,atypical%20pemphigus%20with%20associated%20neoplasia

    3. Paraneoplastic pemphigus | DermNet NZ. (n.d.). Retrieved June 12, 2021, from https://dermnetnz.org/topics/paraneoplastic-pemphigus/