Acquired hemophilia



A rare condition that occurs when the immune system attacks blood-clotting proteins known as Factor VIII, resulting in spontaneous bleeding.

Common Symptoms

Subcutaneous bleeding that causes excessive bruising,  as well as spontaneous bleeding in the muscles and soft tissues.

Coexisting Diseases and Conditions

Systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjogren’s syndrome, temporal arteritis, inflammatory bowel disease, diabetes, respiratory and dermatological diseases, and hematological malignancies.

Risk Factors and Prevalence

A variety of pharmaceutical and infectious triggers such as penicillin, antibiotics, and hepatitis B and C can cause acquired hemophilia. The disease is more common in adults than in children.


  1. Article Sources
    1. Haider MZ, Anwer F. Acquired Hemophilia. [Updated 2021 May 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:

    2. Yousphi, A. S., Bakhtiar, A., Cheema, M. A., Nasim, S., & Ullah, W. (2019). Acquired Hemophilia A: A Rare but Potentially Fatal Bleeding Disorder. Cureus, 11(8), e5442.

    3. NORD (National Organization for Rare Disorders). (2021, April 30). Acquired hemophilia. NORD (National Organization for Rare Disorders).