Overview
A rare condition that occurs when the immune system attacks blood-clotting proteins known as Factor VIII, resulting in spontaneous bleeding.
Acquired hemophilia
Common Symptoms
Subcutaneous bleeding that causes excessive bruising, as well as spontaneous bleeding in the muscles and soft tissues.
Coexisting Diseases and Conditions
Systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjogren’s syndrome, temporal arteritis, inflammatory bowel disease, diabetes, respiratory and dermatological diseases, and hematological malignancies.
Risk Factors and Prevalence
A variety of pharmaceutical and infectious triggers such as penicillin, antibiotics, and hepatitis B and C can cause acquired hemophilia. The disease is more common in adults than in children.
Recent Research
- Acquired hemophilia A (AHA) due to anti-SARS-CoV-2 vaccination: A systematic review (2023)
- Acquired Hemophilia A: An Update on the Etiopathogenesis, Diagnosis, and Treatment (2023)
- Acquired Hemophilia Associated with Rheumatic Diseases: A Case-Based Systematic Review (2022)
- RNA sequencing suggests that non-coding RNAs play a role in the development of acquired haemophilia (2023)
Sources
- Article Sources
Haider MZ, Anwer F. Acquired Hemophilia. [Updated 2021 May 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560494/
Yousphi, A. S., Bakhtiar, A., Cheema, M. A., Nasim, S., & Ullah, W. (2019). Acquired Hemophilia A: A Rare but Potentially Fatal Bleeding Disorder. Cureus, 11(8), e5442. https://doi.org/10.7759/cureus.5442
NORD (National Organization for Rare Disorders). (2021, April 30). Acquired hemophilia. NORD (National Organization for Rare Disorders). https://rarediseases.org/rare-diseases/acquired-hemophilia/.