Autoimmune Disease List

last updated May 2020

There are over 90 known autoimmune diseases and counting, affecting at least 14.7 to 23.5 million Americans* – though research indicates that numbers have been growing steadily for years.

Many more conditions are autoimmune-related, or include suspected autoimmune components. With regard to some conditions, there can be differing opinions and conflicting research on various aspects and their relationships with autoimmunity.

This is an evolving list since many autoimmune diseases overlap, co-exist, and share symptoms; some of the diseases listed here are variants or subtypes of other diseases. Also noted are rare autoimmune conditions – in the U.S., this means any disease affecting fewer than 200,000 people. Our understanding of these conditions is constantly shifting as more information comes to light. 

The collection below is meant to serve as a helpful guide, and a starting point for your own research as a person with diagnosed or undiagnosed conditions – whether you’re unsure if you have an autoimmune disease or you think you may have more than one (having three or more is known as Multiple Autoimmune Syndrome or MAS).

*NOTE: GAI finds this number to be the most reputable estimation of autoimmune disease (AD) prevalence in the U.S. Nevertheless, we acknowledge that determining prevalence is a challenging task, and there are currently no up-to-date statistics. Taking into account undiagnosed and misdiagnosed individuals, as well as the rise in AD over the past few years, the number of cases in the U.S. is likely much higher.

*autoimmune-related or suspected autoimmune disorder
rare disorder +


Acute disseminated encephalomyelitis (ADEM) +

Acute hemorrhagic leukoencephalitis (AHLE) / Hurst’s disease +

Agammaglobulinemia, primary +

Alopecia areata +

Ankylosing spondylitis

Antiphospholipid syndrome (APS) +

Aplastic anemia +


*Autism spectrum disorders (ASD)

Autoimmune Addison’s disease (AAD) +

Autoimmune dysautonomia

Autoimmune encephalitis

Autoimmune gastritis

Autoimmune hemolytic anemia (AIHA) +

Autoimmune hepatitis (AIH) +

Autoimmune hyperlipidemia

Autoimmune hypophysitis

Autoimmune inner ear disease (AIED)

Autoimmune lymphoproliferative syndrome (ALPS)

Autoimmune myocarditis

Autoimmune oophoritis +

Autoimmune orchitis

Autoimmune pancreatitis (AIP) / Immunoglobulin G4-Related Disease (IgG4-RD)

Autoimmune polyglandular syndromes, Types I, II, & III +

Autoimmune progesterone dermatitis

*Autoimmune sudden sensorineural hearing loss (SNHL)

Autoimmune thyroiditis


Balo disease +

Behçet’s disease +

*Birdshot chorioretinopathy / birdshot uveitis

Bullous pemphigoid +


*Castleman disease +

Celiac disease

*Chagas disease

*Chronic fatigue syndrome / myalgic encephalomyelitis

Chronic inflammatory demyelinating polyneuropathy (CIDP) +

*Chronic urticaria (CU)

Churg-Strauss syndrome / eosinophilic granulomatosis with polyangiitis (EGPA) +

Cicatricial pemphigoid +

Cogan’s syndrome +

Cold agglutinin disease +

CREST syndrome

Crohn’s disease (CD)

*Cronkhite-Canada syndrome (CSS) +

*Cryptogenic organizing pneumonia (COP)


Dermatitis herpetiformis +

Dermatomyositis +

Diabetes, type 1

Discoid lupus

*Dressler’s syndrome / postmyocardial infarction / postpericardiotomy syndrome



Eosinophilic fasciitis +

*Erythema nodosum

*Essential mixed cryoglobulinemia +

Evans syndrome +


*Fibrosing alveolitis


*Giant cell arteritis / temporal arteritis / Horton’s disease +


Goodpasture’s syndrome / Anti-GBM/anti-TBM disease

Granulomatosis with polyangiitis (GPA) / Wegener’s granulomatosis +

Grave’s disease +

Guillain-Barré syndrome (GBS) +


Hashimoto’s thyroiditis

Henoch-Schönlein purpura / IgA vasculitis +

Herpes gestationis / pemphigoid gestationis +



IgA nephropathy +

Immune thrombocytopenia (ITP) / autoimmune thrombocytopenic purpura +

*Interstitial cystitis


Juvenile idiopathic arthritis


*Kawasaki disease +


Lambert-Eaton myasthenic syndrome (LEMS) +

*Leukocytoclastic vasculitis

Lichen planus +

*Lichen sclerosus +

*Ligneous conjunctivitis +

Linear IgA disease (LAD)

Lupus nephritis

*Lyme disease


Ménière’s disease

Microscopic polyangiitis (MPA)

Mixed connective tissue disease (MCTD) +

*Mooren’s ulcer

*Mucha-Habermann disease +

Multiple sclerosis (MS)

Myasthenia gravis (MG) +


Neuromyelitis optica (NMO) / Devic’s disease +

*Narcolepsy +

Non-length-dependent small fiber sensory neuropathy


Ocular cicatricial pemphigoid +

*Opsoclonus-myoclonus syndrome (OMS) +


Palindromic rheumatism

Palmoplantar pustulosis (type of psoriasis)  +

Paraneoplastic cerebellar degeneration +

Paraneoplastic pemphigus +

Paroxysmal nocturnal hemoglobinuria (PNH) +

*Peripheral uveitis / pars planitis +

Parsonage Turner syndrome +

Pemphigus foliaceus +

Pemphigus vulgaris +

*Pernicious anemia +

POEMS syndrome +

Polyarteritis nodosa +

Polymyalgia rheumatica +

Polymyositis +

Primary biliary cirrhosis (PBC)


Psoriatic arthritis +

*Pulmonary fibrosis, idiopathic (IPF) +

Pure red cell aplasia +

*Pyoderma gangrenosum +


Raynaud’s disease

Reactive arthritis / Reiter’s syndrome

*Reflex sympathetic dystrophy

Relapsing polychondritis +

*Restless leg syndrome / Willis-Ekbom disease +

Rheumatic fever

Rheumatoid arthritis



Schmidt syndrome / autoimmune polyendocrine syndrome type II +


Scleroderma +

*Serpiginous choroidopathy +

Sjögren’s syndrome

*Stiff person syndrome (SPS) +

Systemic lupus erythematosus (SLE)

*Subacute bacterial endocarditis (SBE)

*Sympathetic ophthalmia


*Takayasu’s arteritis

Testicular autoimmunity

*Tolosa-Hunt syndrome +

*Transverse myelitis (TM) +

*Tubulointerstitial nephritis uveitis syndrome (TINU)


Ulcerative colitis (UC) +

Undifferentiated connective tissue disease (UCTD)

*Uveitis, anterior

*Uveitis, intermediate

*Uveitis, posterior +




*Vogt-Koyanagi-Harada syndrome (VKH) +

Sources of information

With thanks to The Autoimmune Epidemic by Donna Jackson Nakazawa. Her well-researched book is rich with research and insights from various experts in the field of autoimmunity.

Global Autoimmune Institute Mini Logo

Join Our Community!Stay Informed. Stay Hopeful.

Sign up for resources, insights, and updates on autoimmune disease and living with chronic illness.