Genetics

New Theory Explaining Higher Prevalence of Autoimmunity in Females

An article published this week explores a new explanation for the longstanding question of why women are more prone to developing autoimmune disease. Previous theories focus on sex hormones and gene regulation, but this new theory adds complexity by suggesting that a molecular coating found on one of women’s X chromosomes, related to a process called X-chromosome inactivation (which dampens the function of one X chromosome in the majority of XX cells), may trigger immune responses.

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New Treatments Based on Specific Genetic and Autoimmune Causes of Psychiatric Illness Under Investigation

Doctors and researchers have found that some patients with refractory schizophrenia and schizoaffective disorder have underlying lupus, and once treated for lupus, their psychiatric symptoms disappear. Dr. Sander Marx found that two patients with schizophrenia and schizoaffective disorder who were completely detached from reality and had been institutionalized for decades almost completely recovered following treatment for lupus.

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The Autoimmune Tautology: An update

An Autoimmune Tautology refers to the fact that autoimmune diseases share several clinical signs and symptoms, physiopathological mechanisms, and genetic factors that support their having a common ancestor.

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Unexpected Discovery in RA

Rheumatoid Arthritis (RA) is a systemic, inflammatory autoimmune disease in which the immune system attacks the synovial membrane of the joints. While exploring the cause of inflammation in rheumatoid arthritis, researchers found that deleting a gene called ELM01 actually decreases, rather than increases, joint inflammation in mice.

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